A wizard from another planet named Yen Sid, gives Mickey and his friends super-powers to fight against evil.
Mickey Mouse/Mighty Mouse- The leader of the Disney Defenders, he has super-stength and flight power.
Minnie Mouse/Mighty Mousette- The Disney Defenders second-in-command, and Mickey's girlfriend, she has telekinesis.
Donald Duck/Destructo Duck- He fires beams of energy.
'Goofy/'Captain Goof- The comic relief of the Disney Defenders, he has shapeshifting powers.
Daisy Duck/Delighful Duck- She is Donald's girlfriend has invisibility powers.
Pluto/The Incredible Mutt- The Disney Defenders mascot, he can transform into a giant monster dog at will.
Yen Sid- The advisor of the Disney Defenders, he is a master of magic.
The Phantom Blot- The Disney Defenders most dangerous enemy, he seems to know Yen Sid somehow, his body is made of living ink.
Pete/Power Pete- Has super-strength.
The Beagle Boys- A gang of thugs often hired by Pete.